Gnai2 and interferon
WebOct 1, 2024 · The inducible adipocyte-specific Gnai2-deficient mouse line was termed Gnai2 ako (genotype: Gnai2 fl/fl; AdipoqCreER T2+/tg).By crossing AdipoqCreER T2+/tg mice [] with mice carrying floxed Gnai2 alleles [], the expected genotypes were achieved.The different genotypes were born at expected Mendelian ratios and were viable and fertile. … WebGuanine nucleotide-binding protein G (i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene. [5] [6] [7] Interactions [ edit] GNAI2 has been shown to interact with: EYA2, [8] GPSM2, [9] [10] Interleukin 8 receptor, alpha, [11] [12] MDFI, [13] RGS5, [14] [15] and RIC8A. [16] References [ edit]
Gnai2 and interferon
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WebIn molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression … Webwww.ncbi.nlm.nih.gov
WebGNAI2 INFORMATION. Proteini. Full gene name according to HGNC. G protein subunit alpha i2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. GNAI2 (GIP, GNAI2B) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebJul 29, 2024 · Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) is a member of the “inhibitory” class of α-subunits, and recent studies showed that Gnai2 deficiency is known to cause reduced weight in mice. However, the role of GNAI2 in hepatocytes, particularly in the context of liver inflammation and lipid metabolism, remains to be ...
• Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". International Journal of Developmental Neuroscience. 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID 10978845. S2CID 21002590. • Offermanns S, Schultz G, Rosenthal W (Feb 1991). "Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells". The Journal of Bio… WebJan 11, 2024 · After univariate, Lasso regression, and multivariate stepwise screening, two key prognostic genes (GNAI2, PSME1) were identified. Meanwhile, a risk prognosis model was constructed, which can predict the overall survival rate in the validation set. ... antigen presentation, that is, gamma interferon reaction, etc. Cell components include the MHC ...
WebAlpha interferon is produced by white blood cells other than lymphocytes, beta interferon by fibroblasts, and gamma interferon by natural killer cells and cytotoxic T lymphocytes (killer T cells). All interferons inhibit viral replication by interfering with the transcription of viral nucleic acid.
WebGnai2 fx/fx mice carry loxP sites inserted into the introns that flank exons 2 and 4. Breeding established offspring (cGαi2 −/−) that were homozygous for the floxed Gnai2 alleles and heterozygous for Cre and Omp (Gnai2 fx/fx Omp cre/+). In these mice, Cre-mediated Gnai2 deletion was restricted to Omp-positive cells. faa aviation maintenance technician schoolWebMar 14, 2024 · Data show that guanine nucleotide-binding protein G (i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo. faa aviation medical examiner courseWebJul 28, 2024 · Loss-of-function assays showed that the GNAI2 antibody detects GNAI2 whereas both GNAI1 and GNAI3 antibodies detect endogenous GNAI3 (Supplementary Fig. 1b, c) consistent with MCF7 cells ... does hcg rise before implantationWebG protein subunit α i2 (GNAI2) belongs to the isotrimeric guanine nucleotide-binding protein (G protein) family [ 9 ]. Existing studies suggest that high GNAI2 expression can promote … faa aviation newsWebAug 14, 2024 · Increased expression of GNAi2, which encodes the α-subunit of G-protein i2, has been correlated with the late-stage progression of ovarian cancer. GNAi2 , also … does hcg injections cause cancerWebJan 14, 2014 · Human GNAI2 transcriptome meta-analysis. To further confirm our results, we analyzed data from the NIH GEO database. The Nature 2011 dataset confirms the trend and indicated 266 samples, or 84.4% of cancer, were below the normal mean expression value of 0.38 ± 0.09 (p < 0.004) and 84 samples, or 26.7%, were below the absolute … faa aviation safetyWebWhat is an interferon? Interferon (IFN) proteins are a family of cytokines secreted by host cells to modulate the immune response. As the first class of cytokines discovered, they … faa avs oda office